Comparative transcriptomic profiling of bovine turbinate cells and Madin-Darby bovine kidney cells in response to a non-cytopathic bovine viral diarrhea virus infection

Bovine viral diarrhea virus (BVDV) belongs to the Flaviviridae family and the Pestivirus genus.BVDV is primarily a pathogen of cattle causing acute and persistent infections, but it can also affect other domestic and wild ruminant species. BVDV is one of the major contribute to bovine respiratory disease complex that causes significant economic losses to the U.S. cattle industry. BVDV infections can lead to transient lymphocytopenia, lymph nodes and thymus lymphocytes depletion, and thus immunosuppression. The primary site of BVDV entry into cattle is oronasal route during acute infection and first replicates virus in nasal mucosa. Although BVDV induced transcriptomic changes were done in bovine kidney cells, such studies are yet to be performed with more relevant bovine respiratory epithelial cells. In order to fill this important knowledge gap, the aim of this study was to assess the transcriptomic profiles in primary bovine turbinate cells (BTu) and then compare with kidney cells (MDBK) after infection with a non-cytopathic strain of BVDV. The results from the transcriptomic data from turbinate cells may provide essential insights into novel therapeutic interventions.