Biophysical profiles of the four characteristic proteins.

Values are chosen from distributions of optimal substrates given in Powers et al. [21], as described in the main text. and are the rate and equilibrium constant for misfolding, respectively. Larger values of indicate faster misfolding (), and larger values of indicate more stable misfolded states. and are the rate and equilibrium constant for folding, respectively. Larger values of indicate faster folding (), and larger values indicate more stable native states. is the aggregation rate, and is the critical concentration for aggregation, which controls the disaggregation rate as . Larger values of indicate faster aggregation, and larger indicates lower stability of the aggregated states.