Summary of virological and histological findings in human lung graft, mouse tissues and blood following Nipah virus challenge.

N/A = Not applicable. Direct = injection into the graft, resulting in primary infection; Indirect = secondary infection resulting from virus dissemination from the direct infected lung graft. IP = Intraperitoneal challenge. SC = Subcutaneous challenge. Infectious virus was determined in human lung and mouse tiisues and whole blood by TCID50% as described in Materials & Methods. Viral antigen was detected with an anti N antibody as described in Materials & Methods. Histopathology is based on H&E stained lung sections described in Materials & Methods.
* = data available on day 10 post infection only.
# = for control NSG mice only.
+++ = high virus titer/intense immunostaining/extensive histopathological changes. + = low virus titer/low intensity immunostaining, − = not detected.