Fabrication of Polycaprolactone Electrospun Fibres with Retinyl Acetate for Antioxidant Delivery in a ROS-Mimicking Environment

In the treatment of head and neck cancers, radiotherapy can cause salivary gland dysfunction, significantly impacting the patient’s quality of life. Tissue engineering approaches are used to mimic the microenvironment of the tissue and can mediate the damaged microenvironment via bioactive compounds, to support the delivery, survival, and proliferation of new, healthy cells into the damaged environment. In this study, retinyl acetate, a derivative of vitamin A, was successfully incorporated into electrospun polycaprolactone fibres. The results provided in this dataset show the gene expression of BCL2, CAT, and GPx1. The most significant result was the upregulation in the expression of GPx1, an antioxidant enzyme, when cultured under both normal conditions and under a simulated oxidative stress environment. The dataset relates to the upcoming publication Lorna Westwood, Elaine Emmerson, Anthony Callanan (in submission). "Fabrication of Polycaprolactone Electrospun Fibres with Retinyl Acetate for Antioxidant Delivery in a ROS-Mimicking Environment".