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PLK1 phosphorylation of Epstein-Barr virus nuclear antigen 2

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NIAID Data Ecosystem2026-03-12 收录
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https://www.omicsdi.org/dataset/pride/PXD022970
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The Epstein-Barr virus nuclear antigen 2 (EBNA2) initiates and maintains the proliferation of infected B cells. In search of additional cellular strategies, that control EBNA2 function, we have performed a label-free mass spectrometry-based quantification of cellular proteins in EBNA2 immuno-precipitates and found polo-like kinase 1 (PLK1) to be bound to EBNA2. EBNA2/PLK1 complex formation is strongly enforced by EBNA2 S379 phosphorylation catalyzed by the mitotic CYCLIN B/CDK1 complex.
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2021-08-22
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