Overview of the quantitative influx characteristics (± 65% confidence limits) of the five investigated CPPs based on linear and biphasic modeling of the multiple time regression analysis data.

Kin = Unidirectional influx rate.Vi = Initial brain distribution volume.V0 = Vascular brain distribution volume, experimentally determined as the brain distribution volume of radioiodinated BSA.Vg = Tissue brain distribution volume.K1 = Unidirectional clearance or slope of the initial phase of the brain influx curve.K = Net clearance or slope of the plateau phase of the brain influx curve.Overview of the quantitative influx characteristics (± 65% confidence limits) of the five investigated CPPs based on linear and biphasic modeling of the multiple time regression analysis data.