Gene changes associated with deletion of Esrrg in spiny projection neurons in mice using RNA sequencing

Purpose: The goal of this study is to understand what gene changes are associated with removal of Esrrg in spiny projection neurons from the mouse striatum using injection of AAV for CamKcre Methods: Striatum from mice with or without deletion of Esrrg using AAV:CamKCre were aged to 1 month, striata were extracted and flash frozen on dry ice. RNA was isolated using the trizol method and samples were sent for sequencing. Striatal mRNA profiles of mice 1 month post deletion of Esrrg in the striatum compared to mice with no Esrrg deletion.