Frequencies of antibodies against common infectious agents among MS patients with and without the HLA-DRB1*0405 allele and healthy controls.

*apcorr = 0.0324, as compared with HCs.*bpcorr = 0.0033, as compared with HLA-DRB1*0405 (+) MS.The age of patients during examination was not significantly different among HCs and MS patients, regardless of the presence or absence of the DRB1*0405 allele (mean ± SD in years; 35.22±12.18 in DRB1*0405-positive MS patients, 40.74±12.41 in DRB1*0405-negative MS patients, and 38.93±12.11 in HCs).EBV, Epstein-Barr virus; HCs, healthy controls; MS, multiple sclerosis; VZV, varicella zoster virus.