Supplementary Appendix.docx

In this study we performed a meta-analysis on the currently used targeting drugs for radioiodine-refractory differentiated thyroid cancer (RR-DTC) based on an extensive literature review. This should be the largest meta-analysis of this type with most extensive and comprehensive analyses of various aspects of the therapeutic effects and adverse effects of the drugs in RR-DTC. The results demonstrate the significant therapeutic effects of these drugs and support a measured strategy to balance them against the adverse effects of the drugs. This study also identifies some new drugs that show potential superior benefits in the treatment of RR-DTC, with strong promises for future progress of the field.The results of this study are presented in the manuscript. Other results, including Detailed search strategy, Egger's test results and sensitivity analysis, are included in the supplymentary appendix.