Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with azepane (R)-#50 small molecule inhibitor

Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with azepane (R)-#50 small molecule inhibitor Descriptor: (6M)-4-{[(2R)-azepan-2-yl]methyl}-6-[(4R)-imidazo[1,2-a]pyridin-3-yl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, 1,2-ETHANEDIOL, BENZOIC ACID, ... Authors: Delker, S.L, Abendroth, J, Mayclin, S.J. Deposit date: 2023-10-19 Release date: 2024-11-06 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J.Med.Chem., 67, 2024