Pharmacologically bio-relevant N-functionalized homo-binuclear macrocyclic complexes: synthesis, spectral studies, biological screening, HSA binding, and molecular docking
收藏Taylor & Francis Group2019-10-21 更新2026-04-16 收录
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https://tandf.figshare.com/articles/Pharmacologically_bio-relevant_N-functionalized_homo-binuclear_macrocyclic_complexes_synthesis_spectral_studies_biological_screening_HSA_binding_and_molecular_docking/9874013/1
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The bio-efficient homobinuclear macrocyclic complexes, [Co<sub>2</sub>LCl<sub>4</sub>] · 2H<sub>2</sub>O (<b>1</b>), [Ni<sub>2</sub>LCl<sub>4</sub>] · 2H<sub>2</sub>O (<b>2</b>), [Cu<sub>2</sub>LCl<sub>4</sub>] (<b>3</b>) and [Zn<sub>2</sub>LCl<sub>4</sub>] · H<sub>2</sub>O (<b>4</b>); Tetrachloro[1,1' biphenyl bis(1,6,9,14-tetrahydro-3,4;11,12-diphenyl-1,6,9,14-tetraazacyclohexadecane)] di metal(II).<i>n</i>H<sub>2</sub>O, were synthesized <i>via</i> metal ion controlled reaction using 3,3′-diaminobenzidine, 1,2-bis(bromomethyl)benzene and ethane-1,2-diamine. The stoichiometry, geometry, thermal stability and morphology of the synthesized compounds were inferred by analytical and spectral data. The complex <b>3</b> showed substantial radical scavenging potency. The metal complexes were also screened for comparative antibacterial analysis against different pathogenic microbes. XTT reduction assay further certified this observation to resist biofilm formation. Further, various biophysical measurements were performed for the assessment of human serum albumin-binding affinity of complexes <b>1-4</b>.
提供机构：
Nausheen Bano
创建时间：
2019-09-18
