Genome wide analysis of androgen-regulated miRNAs. Homo sapiens

Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. To investigate the AR signaling, we performed short RNA sequence analysis in AR positive prostate cancer cell line, LNCaP. In addition, we used hormone-refractory prostate cancer model cells, Bicalutamide-resistant (BicR) to explore the differences of androgen signaling in prostate cancer progression. Overall design: Short RNA sequence analysis of androgen-regulated miRNAs in two prostate cancer cells