Crystal structure of the G11 protein heterotrimer bound to FR900359 inhibitor

Crystal structure of the G11 protein heterotrimer bound to FR900359 inhibitor Descriptor: (2R)-2-hydroxy-3-phenylpropanoic acid, (2S,3R)-2-amino-3-hydroxy-4-methylpentanoic acid, (2~{S},3~{R})-2-acetamido-4-methyl-3-oxidanyl-pentanoic acid, ... Authors: Muehle, J, Rodrigues, M.J, Guixa-Gonzalez, R, Deupi, X, Schertler, G.F.X. Deposit date: 2023-08-31 Release date: 2025-03-19 Last modified: 2025-05-21 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers. Proc.Natl.Acad.Sci.USA, 122, 2025