Expression of serum EV microRNAs in aging mice

In Japan in recent years, the population has been aging and the risk of contracting various age-related diseases has increased with age, so there is a need to analyze components characteristic of aging and examine their association with diseases to detect age-related diseases at an early stage. In this study, miRNAs in serum EVs of 82-102-week-old aged mice were analyzed to look for microRNAs (miRNAs) characteristic of aging, and increased expression of mmu-miR-21a-5p was found. Eight-week-old (8w) (n = 5), 82-week-old (82w) (n = 5) and 102-week-old (102w) (n = 3) mice were used in this study. In this study, mice of various ages were used to search for microRNAs whose expression changes in serum with aging.