Pharmacokinetics of 111In-DOTA-non-targeted mIFNα2 and 111In-DOTA- targeted mIFNα2 in mouse blood after a single 20 μg/kg intravenous dose.
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In blood, 111In-DOTA-targeted mIFNα2 had a terminal half-life of 171 hours, clearance of 382 mL/hr/kg, a volume of distribution of 94,650 mL/kg, an AUC(0-∞) of 52.4 hr*ng/mL, an AUC(0–12) of 11.4 hr*ng/mL and an AUC(0–24) of 13.3 hr*ng/mL. 111In-DOTA-non-targeted mIFNα2 had a terminal half-life of 80.4 hours, clearance of 468 mL/hr/kg, a volume of distribution of 54,331 mL/kg and an AUC(0-∞) of 42.7 hr*ng/mL, an AUC(0–12) of 22.4 hr*ng/mL and an AUC(0–24) of 24.6 hr*ng/mL.Pharmacokinetics of 111In-DOTA-non-targeted mIFNα2 and 111In-DOTA- targeted mIFNα2 in mouse blood after a single 20 μg/kg intravenous dose.
创建时间：
2015-12-03
