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AP-PROTAC-2: a Photoswitchable multi-kinase PROTAC

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NIAID Data Ecosystem2026-03-14 收录
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Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

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2022-09-14
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