TNF blockade uncouples toxicity and anti-tumor efficacy induced with an agonist CD40 antibody. TNF blockade uncouples toxicity and anti-tumor efficacy induced with an agonist CD40 antibody

TNF mechanistically links cytokine release and hepatotoxicity triggered by an agonist CD40 antibody, and toxicity can be suppressed by blockade of TNF without affecting anti-tumor efficacy. Overall design: mRNA sequencing of bulk liver tissue collected from wild-type mice at 48 hours after treatment with the CD40 agonist FGK45 (compared to control)