Molecular Epidemiology of Hepatitis E Virus in Hungary between 2018 and 2025.

While hepatitis E virus is endemic in Hungary, information on the circulating sub-types in humans and animals has been limited. Here we report the results of our country-wide molecular surveillance from 2018 to 2025. Viruses detected from serum samples of patients with acute viral hepatitis were genotyped and near-complete genomes were sequenced using next-generation sequencing. The surveillance revealed the presence of a wide range of subtypes, including rare variants and the first detection of HEV-4 in Central Europe.