Methylation data from radiation-induced glioma and reference cohort

Long-term complications such as radiation-induced second malignancies occur in a subset of patient following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). Our study revealed a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets. We performed comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n=25) and ALL (n=8) with reference cohorts representing other pediatric brain tumor entities.