Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumonia

Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumonia (VAP) was a prospective longitudinal observational study of high risk mechanically ventilated children with systematic bacterial and viral analyses of the respiratory tract along with proteomic evaluation of the host response to determine whether specific taxa and patterns of bacterial microbiota contribute to ventilator-associated pneumonia (VAP) risk and whether bacterial communities are modulated by viral infection and host immune responses to increase risk of VAP. Analysis found that in mechanically ventilated children, microbial factors were subtly different at intubation between those who did and did not develop VAP, and changes over time were marginally associated with VAP risk, suggesting other factors may contribute to VAP.