rAAV expressing COBRA HA generates protective and durable immune response
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Mice and ferrets were vaccinated with varying dosages of recombinant adenovirus-associated virus (rAAV) vector expressing a computationally optimized broadly reactive antigen Y2 (COBRA)-derived influenza H1 hemagglutinin (HA). Single administration of a rAAV COBRA HA induces neutralizing and broadly protective antibodies in animals. The data supports the utility of viral vector as a potential approach to improve the influenza seasonal vaccines.
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ImmPort创建时间：
2024-07-25
