Data for: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

Recording and modulating neural activity in vivo enables investigations of the neurophysiology underlying behavior and disease, but there is a dearth of translational tools for simultaneous recording and localized receptor-specific modulation. We addressed this limitation by translating multifunctional fiber neurotechnology previously only available for rodent studies to enable cortical and subcortical neural recording and modulation in macaques. In the premotor cortex and putamen, we recorded single-neuron activity and local field potential oscillations during intracranial GABA infusions while a macaque performed a working memory task. We also recorded neuronal activity during saline, artificial cerebrospinal fluid, and no infusion control experiments. We characterized the dynamic effects of local infusions with multiple time series analysis techniques, including spectrotemporal analysis and state-space modeling. This dataset and accompanying software toolbox provide detailed insight i..., All details regarding data collection and preprocessing can be found in the associated manuscript., All data files are saved as .mat files, which can be opened with MatLab or python. The software is written in MatLab.
The analysis software integrates with the following toolboxes:
Chronux: http://chronux.org/
FOOOF: https://github.com/fooof-tools/fooof 
Neurostat: https://github.com/iahncajigas/nSTAT
PPSSM: https://github.com/josefinacmenendez/PPSSM, # Data for: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

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Simultaneous neuronal recordings and neuromodulation were enabled by multifunctional fiber neurotechnology. This dataset contains neurophysiological and behavioral data recorded from a macaque performing a working memory task. Recordings were performed in the premotor cortex or putamen. During the recordings, there was intracranial neuromodulation.

There are 5 recording types and corresponding files

* pmc\_gaba: Recordings in the premotor cortex with intracranial GABA infusion(s) (n = 4)
* pmc\_sal: Recordings in the premotor cortex with intracranial saline infusion(s) (n = 3)
* pmc\_acsf: Recordings in the premotor cortex with intracranial aCSF infusion(s) (n = 2)
* pmc\_noic: Recordings in the premotor cortex with no intracranial infusion (n = 4)
* put\_GABA: Recording in the putamen with intracranial GABA infusion
* pmc\_noic: Recordings in the putame...