Biphasic Cell Cycle Defect Causes Impaired Neurogenesis in Down Syndrome [CPC RNA-Seq]

Using integrative approach involving human and mouse iPSCs, we have unravelded the cellular and molecular mechanisms of reduced neurogenesis in Down syndome Isogenic normal and Down syndrome iPSCs were differentiated in to cortical progenitor cells (CPCs) for 24 day in vitro(DIV24). CPCs were used for total RNA isolation. A total of 6 samples that is 3 replicates of isogenic normal CPCs and 3 replicates of Down syndrome CPCs were used for mRNA-seq library preperation. Libraries wer subjected to single end high throughout sequencing.