DFT1 cell line CNVs.

Summary of recurrent CNVs associated with DFT1 cell lines. The recurrent CNVs commonly observed in DFT1 cell lines fall into two linked clusters, involving losses on chromosomes 1, 2, and 4 and gains on chromosomes 5 and X, respectively. IDs and coordinates of CNVs part of each cluster are shown, together with genotypes in cell lines and in 18 DFT1 biopsies, which have acquired one or more of the common cell line CNVs. Each independent event, which may be shared between multiple tumours via a common ancestor, has either a “cell line event” or “biopsy event” ID. The tumours associated with each event are listed, together with clade group and metastasis/primary identity if relevant. Tetraploid tumours, together with tetraploid lineage in parentheses, are marked. CNV IDs for each event are shown (see S3 Table). Clonal changes in tetraploid tumours are denoted as subclonal. SC, subclonal; PBM, partial back mutation. (XLSX)