首页/数据集/Imaging-based drug screening combined with moleuclar profiling identifies signatures and drivers of therapy resistance in pediatric AML

Imaging-based drug screening combined with moleuclar profiling identifies signatures and drivers of therapy resistance in pediatric AML

NIAID Data Ecosystem2026-05-02 收录

白血病耐药机制

成像药物筛选

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282426 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-09-01

白血病耐药机制

靶向治疗

Loss-of-function mutations and deletions in the core components of the epigenetic polycomb repressive complex 2 (PRC2) are associated with poor initial treatment response in T-cell acute lymphoblastic

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Acquired MEN1 mutations mediate resistance to Menin inhibition [RNA-seq]. Acquired MEN1 mutations mediate resistance to Menin inhibition [RNA-seq]

白血病耐药机制

MLL1

Acute leukemias driven by rearrangements of the Mixed Lineage Leukemia gene (MLLr) or mutants of Nucleophosmin (NPM1c) require the chromatin adapter protein Menin, encoded by the MEN1 gene, to sustain

NIAID Data Ecosystem10

Mapping the Evolution of T Cell States During Response and Resistance to Adoptive Cellular Therapy

细胞免疫治疗

白血病耐药机制

We investigated single T cell transcriptional states that define donor lymphocyte infusion (DLI) response and resistance from cryopreserved bone marrow mononuclear cells from 15 patients with relapsed

NIAID Data Ecosystem10

Metadata record for the article: Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia

白血病耐药机制

JAK抑制剂开发

Summary This metadata record provides details of the data supporting the claims of the related article: “Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymph

Figshare2021-07-27 更新20

Table S3 from Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia

白血病耐药机制

FLT3抑制剂基因表达

Table S3 shows quizartinib pre-resistance gene expression signatures.

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