Autopsy report summary of patients who died of severe CNS (s-CNS) cryptococcosis.

Cryptococcus autopsy cases for brain immunhistochemistry that have been collated according to the following inclusion criteria based on findings 1 week prior to death: (1.) cryptococcal meningoencephalitis with or without dissemination (CSF India ink OR culture positive), (2.) Glasgow coma score < 8 for > 48 hours, (3.) presence of Babinski or other upper motor neuron signs OR seizure activity, and (4.) exclusion of competing risks.
PMN = polymorphonuclear leukocytes
*PCR of our paraffin embedded brain autopsy specimens revealed C. neoformans in all 5 autopsy specimens.
**tapered off by time of death
1 in remission
Autopsy report summary of patients who died of severe CNS (s-CNS) cryptococcosis.