Regions identified in the Ashkenazi Jewish CD GWAS, replication, and combined association analyses.

aPhysical position in megabases; Genome build NCBI36/hg18.bGenes highlighted by genetic location of the top SNP ±250 kb, ordered by proximity to the top SNP. If the top SNP is intragenic, the gene is indicated in bold font. Additionally, if there is evidence of eQTL effect of LOD≥5 this is indicated with a ♦ symbol and the LOD is given in brackets.cThe risk allele in the AJ cohort with its frequency in healthy controls given in parenthesis.dThe odds ratio for the risk allele in the replication cohort, with ±95% confidence intervals given in parenthesis.e,f,gp-values for the initial discovery GWAS for Crohn's disease in Ashkenazi Jews (Discovery p-value), replication cohort (Replication p-value) and a combined score of both p-values (Combined p-value) are given. Association significance thresholds are 5×10−8, 0.05, and 5×10−8 for discovery, replication and combined p-values, respectively. The significance thresholds of gene regions previously associated in other cohorts are 5×10−6, 0.05 and 5×10−6 for discovery, replication and combined p-values, respectively.