The use of simulation-based sensitivity analyses is fundamental for evaluating and comparing candidate designs of future clinical trials. In this context, sensitivity analyses are especially useful to
This zipped tar ball contains all the files (programs, data sets, program logs, shell scripts for cluster computing, etc.) that were used to produce the results in the paper referenced in the title.
Adaptive two-stage design with treatment selection, also called seamless Phase II/III design, has been recognized to save sample size and time to enhance the development of effective treatments. These