MOLECULAR AND BIOCHEMICAL FOUNDATIONS OF FERMENTOPATHIES: A COMPARATIVE ANALYSIS OF STUDIES BY UZBEKISTANI AND INTERNATIONAL SCIENTISTS

This article analyzes the molecular and biochemical foundations of fermentopathies through the prism of the scientific views of international and local scholars. The study examines the historical and scientific hierarchy from Sir Archibald Garrod’s theory of the “metabolic block” to the modern Nelson-Cox and Severin concepts. The contribution of representatives of the Uzbek school of biochemistry, R.A. Sobirova and A.V. Abrorov, to the regional and clinical study of enzymatic processes is also highlighted. Using phenylketonuria, glycogen storage diseases, and gallstone disease as examples, the article provides a detailed analysis of the pathochemical mechanisms of fermentopathies and puts forward personal conclusions and practical recommendations.