Capturing the onset of PRC2-mediated repressive domain formation (4C-Seq)
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94428
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资源简介：
Our study defines nucleation and spreading regions for Polycomb repressive complex 2 (PRC2), demonstrating the principle of PRC2 domain formation in mammals. We elucidate the role of genome architecture in formation of these domains and identify JARID2 and MTF2 as being crucial for full recruitment of PRC2 to chromatin. In this experiment, we performed 4C-seq in mESCs using nucleation sites, spreading sites, and two control sites as viewpoints.
创建时间：
2019-05-15
