An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553
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https://figshare.com/articles/dataset/An_Expeditious_Synthesis_of_the_MDM2_p53_Inhibitor_AM_8553/2501101
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资源简介：
The development of the structurally complex MDM2/p53
inhibitor
AM-8553 was impeded by the low yield of the initial synthesis. A second
generation synthesis is described that features a Noyori dynamic kinetic
resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted
piperidinone forming reaction to provide AM-8553 in 35.6% yield and
11 steps.
创建时间：
2016-02-20
