Additional file 2 of An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study

Additional file 2: Table S1. Prostate cancer association results for 269 established PCa risk variants from Conti et al. Table S2. Hazard ratio for PCa associated with a 269-SNP PRS. Table S3. Baseline characteristics for General-, EOPC- and LOPC-group from UK Biobank case–control population. Table S4. Odds ratio for PCa associated with a 269-SNP PRS. Table S5. 2,555 Genome-wide significant variants associated with the risk of PCa in the Cox proportional hazard model in UK Biobank. Table S6. 91 Genome-wide significant variants associated with the risk of EOPC in the Cox proportional hazard model in UK Biobank. Table S7. 2500 Genome-wide significant variants associated with the risk of LOPC in the Cox proportional hazard model in UK Biobank. Table S8. 319 independent variants among 1555 Genome-wide significant variants associated with the risk of PCa based on clumping in 1000 Genomes Project. Table S9. 45 independent variants among 223 Genome-wide significant variants associated with the risk of EOPC based on clumping in 1000 Genomes Project. Table S10. 296 independent variants among 1583 Genome-wide significant variants associated with the risk of LOPC based on clumping in 1000 Genomes Project. Table S11. Hazard ratio for PCa associated with the General-, EOPC- and LOPC-PRS based on UK BioBank follow-up cohort. Table S12. Odds ratio for PCa associated with the General-, EOPC- and LOPC-PRS based on UK BioBank case–control population. Table S13. 397 merged SNPs from the 269-SNP PRS and General-PRS. Table S14. 62 merged SNPs from the 269-SNP PRS and EOPC-PRS. Table S15. 375 merged SNPs from the 269-SNP PRS and LOPC-PRS. Table S16. Hazard ratio for PCa associated with the merged-General-, merged-EOPC- and merged-LOPC-PRS based on UK BioBank follow-up cohort. Table S17. Odds ratio for PCa associated with the merged-General-, merged-EOPC- and merged-LOPC-PRS based on UK BioBank case-comtrol population. Table S18. High-confidence traits linked to PCa through two-sample MR analysis. Table S19. High-confidence traits linked to EOPC through two-sample MR analysis. Table S20. High-confidence traits linked to LOPC through two-sample MR analysis.