Expression data from fetal membranes

Genome wide expression profiling was used to identify signifnificantly changed genes in fetal membranes after GBS treatment Genome-wide expression profiles in GBS-inoculated human extraplacental membranes in vitro were used to identify transcriptomic pathways altered by GBS . Using bioinformatics analysis of these expression profiles we aimed to test our hypothesis that GBS activates pathways related to inflammation and premature birth in human extraplacental membranes. RNA was analyzed using membranes obtained from 4 separate women for each condition (GBS treated and controls) and for each timepoint (4, 8 and 24 hours) for a total of 24 total samples.