Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA

Exposure to cigarette smoke induces the angiogenic activation of the endothelial cells in the cancer field by selective degradation of mature microRNA-1. This change can be detected in the lungs of non-small cell lung cancer patients and correlates with their smoking burden. We collected tumor (T) and lung tissue adjacent to tumor (AT) from NSCLC patients (6 smokers and 3 non-smokers). We first performed a multi-step comparative transcriptome analysis on those tissue samples and compared the expression of genes between the T and AT samples in smokers and non-smokers.