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6mer seed toxicity in tumour suppressive microRNAs

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111379
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资源简介:
6mer seed toxicity in tumour suppressive microRNAs Samples of human ovaries were generated by deep sequencing, using Illumina HiSeq4000. HeyA8 cells treated with Doxorubicin, Carboplatinum, Etoposide. We provide evidence that miR-34a is toxic to cancer cells mostly through its toxic 6mer seed sequence. RNA isolated from HeyA8 cells 48 hrs after transfection with either a nontargeting siRNA (siNT2), miR-34a Seed, pre-miR-NC, or pre-miR-34a was subjected to deep sequencing, using Illumina HiSeq4000.
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2022-09-08
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