Nanostructural characterisation of protein interactions with lipid bilayer membranes: basis for biosensor development

This proposal is part of a larger project that will develop a novel biosensor, based on nanostructured biomimetic lipid membranes, to detect plasma protein biomarkers of severe pathologies. The project will characterise, at the nanoscale, the structure/function relationship linked to the interaction of protein biomarkers with biologically relevant lipids. These interactions will be investigated by means of scattering techniques using large-scale facilities to optimise the lipid composition for specific biomarker detection.