Altered Gene Expression in Antipsychotic Induced Weight Gain

We sequenced the transcriptome of two cohorts of first episode schizophrenia patients before and after three months of treatment with antipsychotics. The first cohort, or the “weight gain” group, included 18 individuals who gained more than 1.5 points of BMI after the treatment. The second cohort, the “no weight gain” group, also included 18 individuals with a change in BMI after the treatment between 1.0 and -1.0 points.