Expression data from human endothelial cells co-cultured with cancer associated fibroblasts

Cancer associated fibroblasts (CAFs) have been shown to plays crucial roles in cancer progression. Although increasing evidence demonstrates that CAFs have important roles in modulating the aggressive phenotypes of cancer cells, their effects on the tumor vasculature remain underexplored. We co-cultured TIME human microvascular endothelial cells (MECs) with either primary human ovarian CAFs or normal ovarian fibroblasts (NFs) to evaluate the effects of CAFs on phenotypes of endothelial cells. RNA samples isolated from TIME cells that had been co-cultured with CAFs or NFs was analyzed using Affymetrix Clariom D human gene expression assays.