Cytolytic activity of the human papillomavirus type 16 E711-20 epitope-specific cytotoxic T lymphocyte is enhanced by heat shock protein 110 in HLA-A*0201 transgenic mice.

Epitope immunization protected mice from tumor growth when addministered 5 days after injection of tumor cells. Although the epitope complex mHSP70-E711-20 and CFA-emulsified epitope immunizations inhibited tumor growth, the tumor bearing mice treated with the epitope complex mHSP110-E711-20 exhibited a stronger decrease in tumor growth than the tumor-bearing mice treated with the other immunogens. Likewise, Kaplan-Meier survival analysis further showed that tumor challenged mice treated with the mHSP110-E711-20 complex exhibited the most markedly prolonged survival.