mouse gut metagenome Raw sequence reads. mouse gut metagenome

Iodine has a key role in maintaining thyroid homeostasis, which is influenced by hormones through almost all nucleated cells and is essential for growth and metabolism. The most common kinds of thyroid dysfunction, hypothyroidism and hyperthyroidism, are markedly related to iodine intake. In addition, the prevalence and incidence of hypothyroidism and hyperthyroidism are much higher in women than in men. However, the link between thyroid homeostasis and the gut microbiota is not yet completely clear, especially when comparing women and men. In this study, the difference in the gut microbiota composition, metabolic syndromes and molecular mechanisms were investigated in female and male mice after iodine supplementation. Our results showed that the female gut microbiota composition was different from that of males in terms of iodine intake. This finding indicated that the high risk of thyroid disease in women could be related to the gut microbiota composition.