Study of the hepatoprotective activity of flavonoides on ethanol-induced injury in HepG2 cells

The goal of this study is to evaluate the potential protective effects of flavonoids, which exist in Chinese propolis, on ethanol-induced injury in HepG2 cells. This in vitro study investigated the produce of ROS, inflammation related factors, and DNA damage induced by ethanol, as well as the alterations of transcription profiles. The underlying mechanisms associated with the beneficial effects of flavonoids on ethanol-induced injuries were analyzed, which might provide evidence for the practical use of flavonoids in the intervene and treatment of ethanol-induced liver injuries.