HER2 IN COMPLEX WITH A COVALENT INHIBITOR
收藏Protein Data Bank Japan2024-11-06 更新2026-04-19 收录
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HER2 IN COMPLEX WITH A COVALENT INHIBITOR Descriptor: 1-[4-[4-[[3,5-bis(chloranyl)-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]-4-(3-fluoranylazetidin-1-yl)butan-1-one, Receptor tyrosine-protein kinase erbB-2 Authors: Bader, G. Deposit date: 2021-08-03 Release date: 2022-07-27 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling. Nat Cancer, 3, 2022
创建时间：
2021-08-03
