Enhancing the fiber degradation efficiency in dairy cattle rumen through engineered bacterial communities

This study advances the rumen microbiome research by combining omics and SynCom engineering through the pipeline of microbiota-bacteria-enzymes-genes and uncovers the role of enzymatic synergy in driving carbohydrate metabolism. These findings provide a framework to harness low-abundance microbes and engineer functional consortia, which are of great importance to improve ruminant feed utilization and biomass conversion. Future work should explore the transcriptome profiles and the metabolic cross-feeding mechanisms of fiber degrading strains in rumen.