Chaperone Mediated Autophagy

In contrary to the vesicle-mediated macroautophagy, the chaperone mediated mechanism of autophagy selectively targets individual proteins to the lysosome for degradation. Chaperones bind intracellular proteins based on recognition motifs and transports them from the cytosol to the lysosomal membrane. Subsequently, the protein is translocated into the lumen for digestion (Cuervo A M et al. 2014, Kaushik S et al. 2018).

与通过囊泡介导的巨自噬相反，伴侣蛋白介导的自噬机制有选择性地将单个蛋白质靶向运送至溶酶体进行降解。伴侣蛋白根据识别基序与细胞内蛋白结合，并将之从细胞质转运至溶酶体膜。随后，该蛋白被转移至腔室内以供消化（Cuervo A M et al. 2014，Kaushik S et al. 2018）。