Single-cell Atlas Reveals Fatty Acid Metabolites Regulate the Functional Heterogeneity of Mesenchymal Stem Cells

Here, using scRNA-seq on bone marrow MSCs, we identified pre-MSCs and lineage-committed MSC clusters, and revealed their potential regulatory mechanisms in MSC lineage commitment. Our data indicated a novel potential role of MSCs responding to fatty acid treatment, which could be applied to in vitro culture. Single-cell RNA-seq on bone marrow MSCs