Integrative Multi-omic Analysis Reveals Conserved Cell-projection Deficits in Human Down Syndrome Brains. Rastogi et al.

NIAID Data Ecosystem2026-05-02 收录

唐氏综合征神经发育

细胞投射缺陷

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Contains raw data and supplementary information for Rastogi et al. publication 2024

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2024-06-03

Data_Sheet_1_Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome.pdf

唐氏综合征神经发育

单细胞转录组学

The intellectual disability (ID) in Down syndrome (DS) is thought to result from a variety of developmental deficits such as alterations in neural progenitor division, neurogenesis, gliogenesis, corti

NIAID Data Ecosystem40

Reversing Abnormal Neural Development by Inhibiting OLIG2 in Down Syndrome Human iPSC Brain Organoids and Neuronal Mouse Chimeras

唐氏综合征神经发育

脑类器官基因干预

Down syndrome (DS), caused by triplication of human chromosome 21 (HSA21), is the most common genetic origin of intellectual disability. Despite the limited success of current pharmacological interven

NIAID Data Ecosystem30

Additional file 3 of DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

表观遗传学分析

唐氏综合征神经发育

Additional file 3. List of all 500 DMPs called in T21 neural lines.

Figshare2020-03-04 更新20

Burlk and single cell RNA sequencing of neural stem cells derived from human trisomic iPSCs. Burlk and single cell RNA sequencing of neural stem cells derived from human trisomic iPSCs

唐氏综合征神经发育

单细胞转录组学

Down syndrome (DS) is the most common genetic condition that causes intellectual disability in humans. The molecular mechanisms behind the DS phenotype remain unclear. Therefore, in the present study,

NIAID Data Ecosystem40

Supplementary Material for: A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells

唐氏综合征神经发育

中间神经元神经发生

Down syndrome (DS) is a developmental disorder whose mental impairment is due to defective cortical development. Human neural progenitor cells (hNPCs) derived from fetal DS cortex initially produce no

NIAID Data Ecosystem30

Integrative Multi-omic Analysis Reveals Conserved Cell-projection Deficits in Human Down Syndrome Brains. Rastogi et al.

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