Supplemental Figure S3 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
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Supplemental Figure S3. The ATR inhibitor VX-970 sensitizes COLO 205 colorectal cancer cells to SN-38. COLO 205 cells were treated with VX-970 and SN-38 for 48h and cytotoxicity was measured by MTS assay. A. Synergy was analyzed by Bliss at the 95% interval using MacSynergy II software. B. Curve shift analysis.
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2014-12-01
