SARS-CoV-2 reactive and neutralizing antibodies discovered by single cell sequencing of plasma cells and mammalian display

In this study, we describe a technology pipeline that integrates single-cell antibody repertoire sequencing and mammalian display to interrogate the specificity of plasma cells from 16 convalescent patients. Single-cell sequencing allows us to profile antibody repertoire features and identify expanded clonal lineages. The deposited data covers the 132 selected heavy and light chain paired antibodies extracted from single-cell plasma cell sequencing, as well as the analysis of specificity post NGS of mammalian display with patient breakdown.