Replicating the allosteric regulation of biological systems in synthetic nanostructures remains a fundamental challenge in supramolecular chemistry. Here, we report a reconfigurable Pd2L4 nanocage (Ex
The binding and the encapsulation of the 6-aminohexanoic acid (1) and 11-aminoundecanoic acid (2) are achieved in aqueous solution and in crystalline Pyrene-box cages. Unexpectedly, the amino-guanidin
