<b>Innovative methods of managing common drugs in sewage using hydrogen peroxide</b>

Drugs and their bioactive metabolites are continuously introduced into aquatic systems through various pathways, and even at trace concentrations, their presence poses a serious environmental problem. This article simulates the residues of common drugs in wastewater and applies the developed LC-MS/MS method for quantitative analysis of drugs, exploring the efficiency of removing common drugs from wastewater with different ratios of Fenton reagent. The results showed that the analytical performance of the method was good, with good linearity in the dynamic range of 1-100 ng/L for the 10 common drugs, and the R2values were all greater than 0.99. The LODs and LOQs ranged from 0.01-0.443 ng/L and 0.04-1.44 ng/L, respectively. The average relative recoveries ranged from 72.99-117%. In addition, the degradation results showed that 10 common drugs were degraded faster (within 30 min) in 12.5 mL H2O2treatment. Considering the economic and application effects of chemical reagents, the optimal test dose of H2O2in Fenton reagent was determined to be 12.5 mL. The pH of the effluent decreased significantly when Fenton reagent was applied, but higher doses of H2O2did not significantly reduce the pH, and the effect of pH on the degradation of the compounds in this experiment was small. This experiment provides a simple, rapid and low-cost LC-MS/MS method for the detection of drugs in wastewater. It also provides a data reference for the removal of common drugs in wastewater treatment, thus achieving efficient management of drug manufacturing sites and domestic wastewater pollution.